Prevalence of TPMT, ITPA and NUDT 15 genetic polymorphisms and their relation to 6MP toxicity in north Indian children with acute lymphoblastic leukemia.
Sanjeev KheraAmita TrehanPrateek BhatiaMinu SinghDeepak BansalNeelam VarmaPublished in: Cancer chemotherapy and pharmacology (2018)
Polymorphisms in ITPA and NUDT15 have a greater prevalence in the north Indian population. Patients with these SNPs tolerate lower doses of 6MP.