Functional Genomics Identifies Hepatitis-Induced STAT3-TYRO3-STAT3 Signaling as a Potential Therapeutic Target of Hepatoma.
Chia-Liang TsaiJeng-Shou ChangMing-Chin YuChern-Horng LeeTse-Ching ChenWen-Yu ChuangWei-Liang KuoChen-Chun LinShi-Ming LinSen-Yung HsiehPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
Many RTKs are simultaneously involved in HCC development. Hepatitis exerts dual effects on the activation of TYRO3-mediated signaling in HCC cells, which further elicits the "TYRO3-STAT3-TYRO3" signaling loop to facilitate tumor growth. Our findings unveil a previously unrecognized link between RTKs and hepatitis-associated HCC and suggest TYRO3 as a marker and therapeutic target for the HCCs with higher hepatitis activity.