The Genes-Stemness-Secretome Interplay in Malignant Pleural Mesothelioma: Molecular Dynamics and Clinical Hints.
Giulia Maria StellaCaterina MarchioElia BariIlaria FerrarottiFrancesco R BertuccioAntonella Di GennaroDavid Michael AbbottPaola PutignanoIlaria CampoMaria Luisa TorreAngelo G CorsicoPublished in: International journal of molecular sciences (2023)
MPM has a uniquely poor somatic mutational landscape, mainly driven by environmental selective pressure. This feature has dramatically limited the development of effective treatment. However, genomic events are known to be associated with MPM progression, and specific genetic signatures emerge from the exceptional crosstalk between neoplastic cells and matrix components, among which one main area of focus is hypoxia. Here we discuss the novel therapeutic strategies focused on the exploitation of MPM genetic asset and its interconnection with the surrounding hypoxic microenvironment as well as transcript products and microvesicles representing both an insight into the pathogenesis and promising actionable targets.
Keyphrases
- molecular dynamics
- genome wide
- copy number
- stem cells
- density functional theory
- induced apoptosis
- dna methylation
- cell cycle arrest
- machine learning
- epithelial mesenchymal transition
- rna seq
- single cell
- endothelial cells
- cell death
- deep learning
- combination therapy
- signaling pathway
- endoplasmic reticulum stress
- human health
- risk assessment
- climate change
- cell proliferation
- cancer stem cells
- replacement therapy
- smoking cessation