Predictive Performance of a Gentamicin Pharmacokinetic Model in Term Neonates with Perinatal Asphyxia Undergoing Controlled Therapeutic Hypothermia.

Marlotte A A van der VeerTimo R de HaanLinda G W FrankenFloris GroenendaalPeter H DijkWillem P de BoodeSinno SimonsKoen P DijkmanHenrica L M van StraatenMonique RijkenFilip CoolsDebbie H G M NuytemansAnton H van KaamYuma A BijleveldRon A A Mathôtnull null

Published in: Therapeutic drug monitoring (2024)

The results of this external validation study justify the generalizability of the gentamicin dosing recommendations made in the original study for neonates with perinatal asphyxia undergoing controlled TH (5 mg/kg every 36 or 24 h with gestational age 36-41 and 42 wk, respectively) and its applicability in model-informed precision dosing.

Keyphrases

gestational age
birth weight
preterm birth
low birth weight
pregnant women
brain injury
clinical practice