Astragaloside IV Inhibits Mitochondrial-Dependent Apoptosis of the Dorsal Root Ganglion in Diabetic Peripheral Neuropathy Rats Through Modulation of the SIRT1/p53 Signaling Pathway.
Ying BenJuan HaoZhihong ZhangYunzhao XiongCuijuan ZhangYi ChangFan YangHui LiTianya ZhangXiangting WangQingyou XuPublished in: Diabetes, metabolic syndrome and obesity : targets and therapy (2021)
AS-IV can reduce the occurrence of mitochondrial-dependent apoptosis by regulating the SIRT1/p53 pathway. It has a similar therapeutic effect as ALA and is therefore a promising drug for the potential treatment of DPN.
Keyphrases
- oxidative stress
- induced apoptosis
- ischemia reperfusion injury
- signaling pathway
- neuropathic pain
- endoplasmic reticulum stress
- cell cycle arrest
- spinal cord
- type diabetes
- risk assessment
- cell death
- spinal cord injury
- wound healing
- emergency department
- adverse drug
- optic nerve
- electronic health record
- smoking cessation