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An association analysis to identify genetic variants linked to asthma and rhino-conjunctivitis in a cohort of Sicilian children.

Gianluca SottileGiuliana FerranteMarta TorregrossaFabio CibellaGiovanna CilluffoSalvatore FasolaRiccardo AlessandroGregorio SeiditaGiovanni ViegiStefania La Grutta
Published in: Italian journal of pediatrics (2019)
Asthma and rhino-conjunctivitis are common chronic diseases in childhood. In this cross-sectional study, we performed a gene association analysis with current asthma and rhino-conjunctivitis in a cohort of Sicilian children aged 10-15 years. Overall, our findings reveal the importance of different genetic variants at 4p14, 16p12.1, 17q12, 6p12.2 and 17q21.1, identifying possible candidate genes responsible for susceptibility to asthma and rhino-conjunctivitis.
Keyphrases
  • chronic obstructive pulmonary disease
  • lung function
  • allergic rhinitis
  • young adults
  • genome wide
  • gene expression
  • dna methylation