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CTP for the Screening of Vasospasm and Delayed Cerebral Ischemia in Aneurysmal SAH: A Systematic Review and Meta-analysis.

Amer MitchelleVineet Vijay GorolayMatthew AitkenKate HannemanYa Ruth HuoNathan W ManningIrene TanMichael Vinchill Chan
Published in: AJNR. American journal of neuroradiology (2024)
For delayed cerebral ischemia, CTP had a sensitivity of >80%, specificity of >75%, and a low negative likelihood ratio of 0.23. CTP had better performance for the detection of vasospasm, with sensitivity and specificity of >85% and a low negative likelihood ratio of 0.16. Although the accuracy offers the potential for CTP to be used in limited clinical contexts, standardization of CTP techniques and high-quality randomized trials evaluating its impact are required.
Keyphrases
  • cerebral ischemia
  • subarachnoid hemorrhage
  • brain injury
  • blood brain barrier
  • human health
  • climate change