Diastolic Blood Pressure Alleles Improve Congenital Heart Defect Repair Outcomes.
Joseph H BreeyearJacob M KeatonEric S TorstensonAndrew H SmithDerek M KlarinScott M DamrauerPradeep NatarajanSara L Van DriestJeffrey G WeinerPrince J KannankerilTodd L EdwardsPublished in: Circulation research (2022)
These results suggest a genetically determined postsurgical survival advantage for CHD patients with blood pressure increasing alleles. Further study may reveal novel mechanisms contributing to postoperative morbidity and mortality, and this approach may assist in early identification of children at risk for adverse postoperative outcomes.