Development and validation of a mass spectrometry based analytical method to quantify the ratios in hemagglutinin trimers in quadrivalent influenza nanoparticle vaccine - FluMos-v1.
Asif ShajahanCindy X CaiJeremy WolffR Sylvie YangVera B IvlevaDaniel B GowetskiVrc Production ProgramQ Paula LeiPublished in: Analytical methods : advancing methods and applications (2023)
A quadrivalent influenza nanoparticle vaccine (FluMos-v1) offers long-lasting protection against multiple influenza virus strains and is composed of four strains of hemagglutinin trimer (HAT) assembled around a pentamer core. Here we report an LC-MS/MS analytical development and validation method to measure the percentage of each HAT component in FluMos-v1.