Global extracellular vesicle proteomic signature defines U87-MG glioma cell hypoxic status with potential implications for non-invasive diagnostics.
Vineesh Indira ChandranCharlotte WelinderKelin Gonçalves de OliveiraMyriam Cerezo-MagañaAnn-Sofie MånssonMaria C JohanssonGyorgy Marko-VargaMattias BeltingPublished in: Journal of neuro-oncology (2019)
We propose, for the first time, an EV protein signature that could comprehensively reflect the hypoxic status of high-grade glioma cells. The presented data provide proof-of-concept for targeted proteomic profiling of glioma derived EVs, which should motivate future studies exploring its utility in non-invasive diagnosis and monitoring of brain tumor patients.
Keyphrases
- high grade
- end stage renal disease
- single cell
- ejection fraction
- chronic kidney disease
- newly diagnosed
- low grade
- peritoneal dialysis
- prognostic factors
- electronic health record
- label free
- cell therapy
- cancer therapy
- stem cells
- current status
- small molecule
- patient reported outcomes
- drug delivery
- climate change
- deep learning
- data analysis