WNT7A deficit is associated with dysfunctional angiogenesis in pulmonary arterial hypertension.
Ananya ChakrabortyAbinaya NathanMark OrcholskiStuti AgarwalElya A ShamskhouNatasha AuerAnkita MitraEleana Stephanie GuardadoGowri SwaminathanDavid F CondonJoyce YuMatthew McCarraNicholas H JuulAlden MalloryRoberto A Guzman-HernandezKe YuanVanesa RojasJoseph T CrossnoLai-Ming YungPaul B YuThomas SpencerRobert A WinnAndrea FrumpVijaya KaroorTim LahmHaley HedlinJeffrey R FinemanRobert A LafyatisCarsten N F KnutsenCristina M AlviraDavid N CornfieldVinicio A de Jesus PerezPublished in: The European respiratory journal (2023)
Wnt7a promotes VEGF signaling in lung PMVECs and its loss is associated with insufficient VEGF-A angiogenic response. We propose that Wnt7a deficiency contributes to progressive small vessel loss in PAH.