Recombinant RGD-disintegrin DisBa-01 blocks integrin αvβ3 and impairs VEGF signaling in endothelial cells.

Taís M DanilucciPatty K SantosBianca C PachaneGraziéle F D PisaniRafael L B LinoBruna C CasaliWanessa F AlteiHeloisa Sobreiro Selistre-de-Araujo

Published in: Cell communication and signaling : CCS (2019)

Disintegrin inhibition of αvβ3 integrin blocks VEGFR2 signalling, even in the presence of VEGF, which impairs the angiogenic mechanism. These results improve our understanding concerning the mechanisms of pharmacological inhibition of angiogenesis.

Keyphrases

endothelial cells
vascular endothelial growth factor
high glucose
cell adhesion
cell migration
wound healing