Aspirin-induced gastrointestinal damage is associated with an inhibition of epithelial cell autophagy.
Carlos HernandezMaria Dolores BarrachinaJorge Vallecillo-HernándezÁngeles ÁlvarezDolores Ortiz-MasiáJesús Cosín-RogerJuan Vicente EspluguesSara CalatayudPublished in: Journal of gastroenterology (2015)
Our data highlight the importance of autophagy in the gastric mucosa as a protective mechanism when the epithelium is injured. In the stomach, aspirin induces mucosal damage and reduces autophagy, thus, eliminating a protective mechanism that epithelial cells could use to escape death. We hypothesize that the combination of aspirin with drugs that activate autophagy could protect against gastric damage.
Keyphrases
- oxidative stress
- cell death
- endoplasmic reticulum stress
- low dose
- signaling pathway
- diabetic rats
- cardiovascular events
- antiplatelet therapy
- cardiovascular disease
- type diabetes
- high glucose
- electronic health record
- deep learning
- machine learning
- drug induced
- anti inflammatory drugs
- percutaneous coronary intervention
- atrial fibrillation
- stress induced