Susceptibility genes of hyperuricemia and gout.
Yue-Li NianChong-Ge YouPublished in: Hereditas (2022)
Gout is a chronic metabolic disease that seriously affects human health. It is also a major challenge facing the world, which has brought a heavy burden to patients and society. Hyperuricemia (HUA) is the most important risk factor for gout. In recent years, with the improvement of living standards and the change of dietary habits, the incidence of gout in the world has increased dramatically, and gradually tends to be younger. An increasing number of studies have shown that gene mutations may play an important role in the development of HUA and gout. Therefore, we reviewed the existing literature and summarized the susceptibility genes and research status of HUA and gout, in order to provide reference for the early diagnosis, individualized treatment and the development of new targeted drugs of HUA and gout.
Keyphrases
- uric acid
- metabolic syndrome
- human health
- risk assessment
- end stage renal disease
- chronic kidney disease
- systematic review
- risk factors
- climate change
- newly diagnosed
- gene expression
- prognostic factors
- cancer therapy
- peritoneal dialysis
- patient reported outcomes
- patient reported
- genome wide analysis
- bioinformatics analysis