Germline breast cancer susceptibility genes, tumor characteristics, and survival.
Peh Joo HoAlexis J KhngHui Wen LohWeang-Kee HoCheng Har YipNur Aishah Mohd-TaibVeronique Kiak Mien TanBenita Kiat-Tee TanSu-Ming TanErn Yu TanSwee Ho LimSuniza JamarisYirong SimFuh Yong WongJoanne NgeowElaine Hsuen LimMei Chee TaiEldarina Azfar WijayaSoo Chin LeeChing Wan ChanShaik Ahmad BuhariPatrick M Y ChanJuliana J C ChenJaime Chin Mui SeahWai Peng LeeChi Wei MokGeok Hoon LimEvan WooSung-Won KimJong Won LeeMin Hyuk LeeSue K ParkAlison M DunningDouglas F EastonMarjanka K SchmidtSoo-Hwang TeoJingmei LiMikael HartmanPublished in: Genome medicine (2021)
PTV9genes carriership is associated with more aggressive tumors. Variants in other genes might be associated with the survival of breast cancer patients. The finding that PTV carriership is not just associated with higher breast cancer risk, but also more severe and fatal forms of the disease, suggests that genetic testing has the potential to provide additional health information and help healthy individuals make screening decisions.