CD300LF + microglia impede the neuroinflammation following traumatic brain injury by inhibiting STING pathway.
Zhichao LuZongheng LiuChenxing WangRui JiangZiheng WangWeiquan LiaoWei WangJianfeng ChenXingjia ZhuJingwei ZhaoQianqian LiuYang YangPeipei GongPublished in: CNS neuroscience & therapeutics (2024)
Our research indicates that CD300LF reduces neuroinflammation and promotes neurological recovery after TBI, and that microglia are integral to the protective effects of CD300LF in this context. In summary, our findings highlight CD300LF as a critical molecular regulator modulating the adverse actions of microglia following acute brain injury and propose a novel therapeutic approach to enhance outcomes for patients with TBI.
Keyphrases
- brain injury
- traumatic brain injury
- cerebral ischemia
- inflammatory response
- subarachnoid hemorrhage
- nk cells
- lipopolysaccharide induced
- neuropathic pain
- signaling pathway
- liver failure
- lps induced
- transcription factor
- emergency department
- type diabetes
- cognitive impairment
- multiple sclerosis
- intensive care unit
- severe traumatic brain injury
- skeletal muscle
- respiratory failure
- white matter
- acute respiratory distress syndrome
- weight loss
- mechanical ventilation