Effect of Berberine on Hyperuricemia and Kidney Injury: A Network Pharmacology Analysis and Experimental Validation in a Mouse Model.

Qiaoping LiZiwei HuangDefu LiuJingna ZhengJianhui XieJiannan ChenHui-Fang ZengZiren SuYucui Li

Published in: Drug design, development and therapy (2021)

BBR exerts anti-HUA and nephroprotective effects via inhibiting activation of NLRP3 inflammasome and correcting the aberrant expression of URAT1 in kidney. BBR might be a novel therapeutic agent for treating HUA.

Keyphrases

nlrp inflammasome
mouse model
signaling pathway
uric acid