Molecular mechanisms in chloroquine-exposed muscle cells elucidated by combined proteomic and microscopic studies.

Vietxuan PhanDenisa HathaziCorinna PreußeArtur CzechErik FreierGerta ShemaRené P ZahediAndreas Roos

Published in: Neuropathology and applied neurobiology (2023)

We demonstrated that CQ exposure (secondarily) impacts biological processes beyond lysosomal function and linked a variety of proteins with known roles in the manifestation of other neuromuscular diseases.

Keyphrases

induced apoptosis
cell cycle arrest
skeletal muscle
endoplasmic reticulum stress
signaling pathway
case control
oxidative stress
plasmodium falciparum