Molecular characterization of immune checkpoint inhibitor-induced cardiotoxicity reveals IL-17A as a driver of cardiac dysfunction after anti-PD-1 treatment.

Tamás G GergelyDániel KucseraViktória E TóthTamás KovácsNabil V SayourZsófia D DrobniMihály RuppertBalázs PetrovichBence AggZsófia OnódiNóra FeketeÉva PállingerEdit I BuzásLaura I YousifWouter C MeijersTamás RadovitsBéla MerkelyPéter FerdinandyZoltan V Varga

Published in: British journal of pharmacology (2022)

PD-1 blockade induces cardiac dysfunction in mice with increased IL-17 signalling in the thymus. Pharmacological inhibition of IL-17A treatment prevents ICI-induced cardiac dysfunction.

Keyphrases

oxidative stress
left ventricular
high glucose
diabetic rats
type diabetes
heart failure
drug induced
metabolic syndrome