Epigenome-wide DNA methylation analysis of small cell lung cancer cell lines suggests potential chemotherapy targets.

Julia KrushkalThomas SilversWilliam C ReinholdDmitriy SonkinSuleyman VuralJohn ConnellySudhir VarmaPaul S MeltzerMark KunkelAnnamaria RapisardaDavid EvansYves PommierBeverly A Teicher

Published in: Clinical epigenetics (2020)

Multiple associations indicate potential epigenetic mechanisms affecting SCLC response to chemotherapy and suggest targets for combination therapies. While many correlations were not specific to SCLC lineages, several lineage markers were associated with specific agents.

Keyphrases

dna methylation
small cell lung cancer
gene expression
genome wide
locally advanced
human health
single cell
risk assessment
copy number
chemotherapy induced