Disordered hemostasis associated with severely depressed fibrinolysis demonstrated using a simultaneous thrombin and plasmin generation assay during L-asparaginase induction therapy in pediatric acute lymphoblastic leukemia.
Takashi IshiharaKeiji NogamiSatoshi OchiToshiaki IshidaYoshiyuki KosakaAkihisa SawadaMasami InoueShinya OsoneToshihiko ImamuraHajime HosoiMidori ShimaPublished in: Pediatric blood & cancer (2019)
The results demonstrated that hemostatic dynamics appeared to shift to a hypercoagulable state with marked hypofibrinolysis associated with L-Asp therapy, especially in patients ≥10.0 years old following the BFM regimen.