EphB2 Receptor Promotes Dermal Fibrosis in Systemic Sclerosis.

Erika S A EgalSeverin Donald KamdemMasaaki YoshigiChing-Chu YangSarah PellizzariErnest M KameniMy N HelmsShervin AssassiMark HenkemeyerTracy M Frech Patrice N Mimche

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2024)

Our data implicate TGF-β regulation of EphB2 overexpression and kinase-mediated forward signaling in the development of dermal fibrosis in SSc. EphB2 thus represents a potential new therapeutic target for SSc.

Keyphrases

systemic sclerosis
interstitial lung disease
cell proliferation
electronic health record
transforming growth factor
wound healing
big data
liver fibrosis
transcription factor
protein kinase
human health
risk assessment
data analysis