Pharmacokinetics and pharmacodynamics of dexmedetomidine-induced vasoconstriction in healthy volunteers.

Published in: British journal of clinical pharmacology (2018)

We found that dexmedetomidine-induced vasoconstriction is concentration dependent over time. Dexmedetomidine PK were best estimated by a three-compartment model with allometric scaling. Our results may contribute to future modelling of dexmedetomidine-induced haemodynamic effects.

Keyphrases

high glucose
diabetic rats

cardiac surgery
drug induced

oxidative stress

endothelial cells