Allosteric Modulation of NMDARs Reverses Patients' Autoantibody Effects in Mice.

Marija Radosevic Jesús PlanagumàFrancesco MannaraAraceli MelladoEsther AguilarLidia Sabater Jon Landa Anna García-Serra Estibaliz Maudes Xavier GasullMike LewisJosep O Dalmau

Published in: Neurology(R) neuroimmunology & neuroinflammation (2021)

An oxysterol biology-based PAM of NMDARs is able to reverse the synaptic and memory deficits caused by CSF from patients with anti-NMDAR encephalitis. These findings suggest a novel adjuvant treatment approach that deserves future clinical evaluation.

Keyphrases

clinical evaluation
end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
traumatic brain injury
prognostic factors
early stage
small molecule
working memory
type diabetes
high fat diet induced
insulin resistance
combination therapy
skeletal muscle
wild type
prefrontal cortex