A novel, small anti-HBV compound reduces HBsAg and HBV-DNA by destabilizing HBV-RNA.

Takehisa WatanabeSanae HayashiYan ZhaoyuHiroki InadaKatsuya NagaokaMasakuni TateyamaYasuhito Tanaka

Published in: Journal of gastroenterology (2024)

We have identified SAG-524 as novel and orally bioavailable HBV-RNA destabilizers which can reduce HBsAg and HBV-DNA levels, and possibly contribute a functional cure.

Keyphrases

hepatitis b virus
liver failure
circulating tumor
single molecule
cell free