Detection of archived lamivudine-associated resistance mutations in virologically suppressed, lamivudine-experienced HIV-infected adults by different genotyping techniques (GEN-PRO study).
Rocío MontejanoLourdes Dominguez-DominguezRosa de MiguelDavid Rial-CresteloAndrés Esteban-CantosPaula Aranguren-RivasMónica García-ÁlvarezBelén AlejosOtilia BisbalMireia Santacreu-GuerreroAsunción HernandoLaura Bermejo-PlazaJulen CadiñanosMario MayoralJuan Miguel CastroVictoria MorenoLuz Martin-CarboneroBerta RodésRafael DelgadoRafael RubioFederico PulidoJose Ramon ArribasPublished in: The Journal of antimicrobial chemotherapy (2021)
Proviral DNA Sanger sequencing does not detect the majority of historical lamivudine RAMs. NGS increases the sensitivity of detection at lower thresholds, although the relevance of these minority populations with lamivudine RAMs needs further evaluation.