Improvement of endurance of DMD animal model using natural polyphenols.
Clementina SitziaAndrea FariniFederica ColleoniFrancesco FortunatoPaola RaziniSilvia ErraticoAlessandro TavelliFrancesco FabriziMarzia BelicchiMirella MeregalliGiacomo Pietro ComiYvan TorrentePublished in: BioMed research international (2015)
Duchenne muscular dystrophy (DMD), the most common form of muscular dystrophy, is characterized by muscular wasting caused by dystrophin deficiency that ultimately ends in force reduction and premature death. In addition to primary genetic defect, several mechanisms contribute to DMD pathogenesis. Recently, antioxidant supplementation was shown to be effective in the treatment of multiple diseases including muscular dystrophy. Different mechanisms were hypothesized such as reduced hydroxyl radicals, nuclear factor-κB deactivation, and NO protection from inactivation. Following these promising evidences, we investigated the effect of the administration of a mix of dietary natural polyphenols (ProAbe) on dystrophic mdx mice in terms of muscular architecture and functionality. We observed a reduction of muscle fibrosis deposition and myofiber necrosis together with an amelioration of vascularization. More importantly, the recovery of the morphological features of dystrophic muscle leads to an improvement of the endurance of treated dystrophic mice. Our data confirmed that ProAbe-based diet may represent a strategy to coadjuvate the treatment of DMD.
Keyphrases
- duchenne muscular dystrophy
- muscular dystrophy
- skeletal muscle
- nuclear factor
- resistance training
- toll like receptor
- high intensity
- high fat diet induced
- physical activity
- type diabetes
- weight loss
- electronic health record
- metabolic syndrome
- gene expression
- adipose tissue
- replacement therapy
- big data
- anti inflammatory
- wild type
- soft tissue