Clinical, environmental and histological distribution of BRAF, NRAS and TERT promoter mutations among patients with cutaneous melanoma: a retrospective study of 563 patients.
E Manrique-SilvaS RachakondaD Millán-EstebanZ García-CasadoCelia RequenaVíctor TravesRajiv KumarEduardo NagorePublished in: The British journal of dermatology (2020)
The presence of TERT promoter mutations discriminates BRAF- and NRAS-mutated tumours and indicates a higher involvement of ultraviolet-induced damage and tumours with worse melanoma-specific survival than those without any mutation. These observations refine classification of patients with melanoma based on mutational status.