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N-Glycan profiling of chondrocytes and fibroblast-like synoviocytes: Towards functional glycomics in osteoarthritis.

Johannes FuehrerKatharina M PichlerAnita FischerAlexander GiureaDaniela WeinmannFriedrich AltmannReinhard WindhagerHans-Joachim GabiusStefan Toegel
Published in: Proteomics. Clinical applications (2021)
N-Glycosylation reflects phenotypic changes of osteoarthritic cells in vitro. Like chondrocytes, fibroblast-like synoviocytes express N-glycans that are suited to bind galectins, and these proteins serve as inducers of pro-inflammatory markers in these cells. Synoviocytes can thus contribute to disease progression in osteoarthritis in situ.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • endoplasmic reticulum stress
  • oxidative stress
  • signaling pathway
  • single cell
  • cell proliferation
  • cell surface
  • anti inflammatory