N-Glycan profiling of chondrocytes and fibroblast-like synoviocytes: Towards functional glycomics in osteoarthritis.
Johannes FuehrerKatharina M PichlerAnita FischerAlexander GiureaDaniela WeinmannFriedrich AltmannReinhard WindhagerHans-Joachim GabiusStefan ToegelPublished in: Proteomics. Clinical applications (2021)
N-Glycosylation reflects phenotypic changes of osteoarthritic cells in vitro. Like chondrocytes, fibroblast-like synoviocytes express N-glycans that are suited to bind galectins, and these proteins serve as inducers of pro-inflammatory markers in these cells. Synoviocytes can thus contribute to disease progression in osteoarthritis in situ.