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Characterizing the Complexities of Neutrophils with Suppressive Properties.

Marco Antonio Cassatella
Published in: Cancer immunology research (2021)
Several not-yet fully described neutrophil populations exerting either antitumor or suppressive/protumor functions may appear in the circulation of patients with cancer and/or infiltrate tumor tissues. In this issue, Emmons and colleagues provide new information on how complement-dependent "activation" of normal mature neutrophils renders the cells able to inhibit T-cell responsiveness in vitro The data highlight the complexities of understanding the biology of neutrophil-mediated T-cell suppression.See related article by Emmons et al., p. 790.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • gene expression
  • electronic health record
  • endoplasmic reticulum stress
  • big data
  • cell death
  • healthcare