Comparison of neuroprotective effects of a topiramate-loaded biocomposite based on mesoporous silica nanoparticles with pure topiramate against methylphenidate-induced neurodegeneration.

Erfan PariMohammad SheibaniMohammad Reza SazegarSaeedeh MirAshrafsadat MoazamMina KhalilzadehManijeh Motevalian

Published in: Molecular biology reports (2024)

TPM-loaded nanoparticles could be used as neuroprotective agents against MPH-induced neurodegeneration by improving seizure parameters and reducing inflammatory, oxidant, and apoptotic factors.

Keyphrases

high glucose
diabetic rats
drug delivery
oxidative stress
cell death
cancer therapy
drug induced
anti inflammatory
wound healing
working memory