Resting State Alpha Electroencephalographic Rhythms Are Affected by Sex in Cognitively Unimpaired Seniors and Patients with Alzheimer's Disease and Amnesic Mild Cognitive Impairment: A Retrospective and Exploratory Study.
Claudio BabiloniGiuseppe NoceRaffaele FerriRoberta LizioSusanna LopezIvan LorenzoFederico TucciAndrea SoricelliMontserrat ZurrónFernando DíazFlavio NobiliDario ArnaldiFrancesco FamàCarla ButtinelliFranco GiubileiVirginia CipolliniMoira MarizzoniBahar GüntekinEbru YıldırımLutfu HanoğluGörsev YenerDuygu Hünerli GündüzPaolo OnoratiFabrizio StocchiLaura VaccaFernando MaestúGiovanni B FrisoniClaudio Del PercioPublished in: Cerebral cortex (New York, N.Y. : 1991) (2021)
In the present retrospective and exploratory study, we tested the hypothesis that sex may affect cortical sources of resting state eyes-closed electroencephalographic (rsEEG) rhythms recorded in normal elderly (Nold) seniors and patients with Alzheimer's disease and mild cognitive impairment (ADMCI). Datasets in 69 ADMCI and 57 Nold individuals were taken from an international archive. The rsEEG rhythms were investigated at individual delta, theta, and alpha frequency bands and fixed beta (14-30 Hz) and gamma (30-40 Hz) bands. Each group was stratified into matched females and males. The sex factor affected the magnitude of rsEEG source activities in the Nold seniors. Compared with the males, the females were characterized by greater alpha source activities in all cortical regions. Similarly, the parietal, temporal, and occipital alpha source activities were greater in the ADMCI-females than the males. Notably, the present sex effects did not depend on core genetic (APOE4), neuropathological (Aβ42/phospho-tau ratio in the cerebrospinal fluid), structural neurodegenerative and cerebrovascular (MRI) variables characterizing sporadic AD-related processes in ADMCI seniors. These results suggest the sex factor may significantly affect neurophysiological brain neural oscillatory synchronization mechanisms underpinning the generation of dominant rsEEG alpha rhythms to regulate cortical arousal during quiet vigilance.
Keyphrases
- mild cognitive impairment
- resting state
- cognitive decline
- functional connectivity
- cerebrospinal fluid
- magnetic resonance imaging
- type diabetes
- gene expression
- optical coherence tomography
- late onset
- multiple sclerosis
- mass spectrometry
- early onset
- metabolic syndrome
- rna seq
- copy number
- high school
- high frequency
- single cell
- adipose tissue
- computed tomography
- brain injury
- contrast enhanced
- drug induced