Detection and characterization of mutations in genes related to isoniazid resistance in Mycobacterium tuberculosis clinical isolates from Iran.

Pejman BakhtiyariniyaAzar Dokht KhosraviMohammad HashemzadehMohammad Savari

Published in: Molecular biology reports (2022)

This study supports the usefulness of katG and inhA mutations as a predictive molecular marker for INH resistance. Co-detection of katG S315 and inhA-15 mutations identified 73.3% (11 out of 15 isolates) of INH-resistant isolates.

Keyphrases

mycobacterium tuberculosis
loop mediated isothermal amplification
real time pcr
label free
genetic diversity
pulmonary tuberculosis
genome wide
gene expression
quantum dots