Altered Maternal Antibody Profiles in Women With Human Immunodeficiency Virus Drive Changes in Transplacental Antibody Transfer.

Sepideh DolatshahiAudrey L ButlerMark J SiednerJoseph NgonziAndrea G EdlowJulian AdongMadeleine F JenneweinCaroline AtyeoIngrid V BassettDrucilla J RobertsDouglas A LauffenburgerGalit Alter Lisa M Bebell

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)

Perturbed immune-dominance profiles in WHIV shift the balance of immunity delivered to neonates. Perturbed HIV-associated maternal antibody profiles are a key determinant of com-promised neonatal immunity. Maternal vaccination interventions may promote transfer of relevant, effective antibodies to protect HEU children against early-life infections.

Keyphrases

human immunodeficiency virus
antiretroviral therapy
early life
hepatitis c virus
birth weight

hiv infected
pregnancy outcomes
hiv positive
hiv aids
physical activity

young adults
gestational age
pregnant women
body mass index

south africa
men who have sex with men
weight loss
electron transfer