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Altered Maternal Antibody Profiles in Women With Human Immunodeficiency Virus Drive Changes in Transplacental Antibody Transfer.

Sepideh DolatshahiAudrey L ButlerMark J SiednerJoseph NgonziAndrea G EdlowJulian AdongMadeleine F JenneweinCaroline AtyeoIngrid V BassettDrucilla J RobertsDouglas A LauffenburgerGalit AlterLisa M Bebell
Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)
Perturbed immune-dominance profiles in WHIV shift the balance of immunity delivered to neonates. Perturbed HIV-associated maternal antibody profiles are a key determinant of com-promised neonatal immunity. Maternal vaccination interventions may promote transfer of relevant, effective antibodies to protect HEU children against early-life infections.
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