Plastic Scintillator-Based Microfluidic Devices for Miniaturized Detection of Positron Emission Tomography Radiopharmaceuticals.
Mark D TarnNuray Yavuzkanat KızılyerMohammad M N EsfahaniPankaj JoshiNathaniel J BrownNicole PammeDavid G JenkinsStephen J ArchibaldPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2018)
A miniaturized radio-HPLC detector has been developed comprising a microfluidic device fabricated from plastic scintillator in combination with a silicon photomultiplier light sensor, and tested with samples containing a positron-emitting radionuclide, [18 F]fluoride. This cost-effective, small footprint analytical tool is ideal for incorporation into integrated quality control systems for the testing of positron emission tomography (PET) radiopharmaceuticals to good manufacturing practice (GMP) standards.
Keyphrases
- positron emission tomography
- quality control
- label free
- computed tomography
- circulating tumor cells
- high throughput
- single cell
- ms ms
- pet ct
- primary care
- pet imaging
- simultaneous determination
- healthcare
- drinking water
- quantum dots
- loop mediated isothermal amplification
- image quality
- mass spectrometry
- biofilm formation
- high performance liquid chromatography
- liquid chromatography
- quality improvement
- real time pcr
- magnetic resonance imaging
- energy transfer
- escherichia coli
- pseudomonas aeruginosa
- cystic fibrosis
- high resolution
- candida albicans