Clinical translation of hyperpolarized 13 C pyruvate and urea MRI for simultaneous metabolic and perfusion imaging.
Hecong QinShuyu TangAndrew M RiselliRobert A BokRomelyn Delos SantosMark van CriekingeJeremy W GordonRahul AggarwalRui ChenGregory GoddardChunxin Tracy ZhangAlbert ChenGalen ReedDaniel M RuscittoJames SlaterRenuka SriramPeder Eric Zufall LarsonDaniel B VigneronJohn KurhanewiczPublished in: Magnetic resonance in medicine (2021)
The reported technical development and translational studies will lead to the first-in-human dual-agent HP MRI study and mark the clinical translation of the first HP 13 C MRI probe after pyruvate.