Comparing the effects of GBA variants and onset age on clinical features and progression in Parkinson's disease.

Jingru RenXiaoyan ZhanHao ZhouZhiying GuoYi XingHangxing YinChen XueJun WuWeiguo Liu

Published in: CNS neuroscience & therapeutics (2023)

GBA-PD patients exhibited faster cognitive and motor deterioration than early-iPD and late-iPD patients. Thus, subtype classification based on genetic characteristics rather than age at onset could enhance the prediction of PD disease progression.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
prognostic factors
peritoneal dialysis
machine learning
deep learning
copy number
dna methylation