Permethylated NHC-Capped α- and β-Cyclodextrins (ICyDMe ) Regioselective and Enantioselective Gold-Catalysis in Pure Water.
Xiaolei ZhuGuangcan XuLise-Marie ChamoreauYongmin ZhangVirginie Mouriès-MansuyLouis FensterbankOlivia Bistri-AslanoffSylvain RolandMatthieu SollogoubPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2020)
A series of water-soluble encapsulated copper(I), silver(I) or gold(I) complexes based on NHC-capped permethylated cyclodextrins (ICyDMe ) were developed and used as catalysts in pure water for hydration, lactonization, hydroarylation and cycloisomerization reactions. ICyDMe ligands gave cavity-based high regioselectivity in hydroarylations, and high enantioselectivities in gold-catalyzed cycloisomerizations reactions giving up to 98 % ee in water. These ICyDMe are therefore useful ligands for selective catalysis in pure water.