Insulin resistance, bone health, and fracture risk.
Ferah ArmutcuEugene V McCloskeyPublished in: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2024)
In this concise review article, the role of IR in increased risk of osteoporotic fractures in MetS, obesity, and T2DM is discussed and summarised, including consideration of the need for fracture risk assessment as a 'preventive measure', especially in patients with T2DM and chronic MetS with abdominal obesity. Personalised and targeted diagnostic and therapeutic approaches to prevent osteoporotic fractures in IR-related diseases are needed and could make significant contributions to health outcomes.
Keyphrases
- insulin resistance
- bone mineral density
- high fat diet induced
- metabolic syndrome
- risk assessment
- type diabetes
- adipose tissue
- high fat diet
- skeletal muscle
- glycemic control
- weight loss
- polycystic ovary syndrome
- public health
- postmenopausal women
- healthcare
- human health
- weight gain
- body composition
- hip fracture
- cancer therapy
- heavy metals
- soft tissue
- physical activity
- social media
- body mass index
- bone regeneration
- bone loss