Effect of Repeat Vaccination on Immunogenicity of Quadrivalent Cell-Culture and Recombinant Influenza Vaccines Among Healthcare Personnel Aged 18-64 Years: A Randomized, Open-Label Trial.
Manjusha GaglaniSara S KimAllison L NalewayMin Z LevineLaura EdwardsKempapura MurthyKayan DunniganTnelda ZunieHolly GroomSarah BallZuha JeddyDanielle HuntMeredith G WesleySuryaprakash SambharaShivaprakash GangappaLauren GrantWeiping CaoF Liaini GrossMargarita MishinaAlicia M FryMark G ThompsonFatimah S DawoodBrendan FlanneryPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)
In adult HCPs, receipt of RIV two consecutive seasons or the second season was more immunogenic than consecutive egg-based IIV for three of the four components of quadrivalent vaccine. Immunogenicity of ccIIV/ccIIV was similar to that of IIV/IIV. Differences in hemagglutinin antigen content may play a role in immunogenicity of influenza vaccination in consecutive seasons.