Nrf2 Ablation Promotes Alzheimer's Disease-Like Pathology in APP/PS1 Transgenic Mice: The Role of Neuroinflammation and Oxidative Stress.
Peng RenJingwei ChenBingxuan LiMengzhou ZhangBei YangXiangshen GuoZiyuan ChenHao ChengPengfei WangShuaibo WangNing WangGuohua ZhangXu WuDan MaDawei GuanRui ZhaoPublished in: Oxidative medicine and cellular longevity (2020)
Our present results show that Nrf2 deficiency aggravates AD-like pathology in AT mice. This phenotype was associated with increased levels of oxidative and proinflammatory markers, which suggests that the Nrf2 pathway may be a promising therapeutic target for AD.
Keyphrases
- oxidative stress
- dna damage
- ischemia reperfusion injury
- diabetic rats
- induced apoptosis
- traumatic brain injury
- lipopolysaccharide induced
- cognitive decline
- heat shock
- inflammatory response
- skeletal muscle
- cognitive impairment
- lps induced
- adipose tissue
- replacement therapy
- catheter ablation
- blood brain barrier
- brain injury