Graphene oxide-ellagic acid nanocomposite as effective anticancer and antimicrobial agent.
Samer Hasan Hussein-Al-AliSuha Mujahed AbudolehMohd Zobir HusseinSaifullah BulloArul PalanisamyPublished in: IET nanobiotechnology (2021)
In this study, ellagic acid (ELA), a skin anticancer drug, is capped on the surface(s) of functionalised graphene oxide (GO) nano-sheets through electrostatic and π-π staking interactions. The prepared ELA-GO nanocomposite have been thoroughly characterised by using eight techniques: Fourier-transform infrared spectroscopy (FTIR), zeta potential, X-ray diffraction (XRD), thermogravimetric analysis (TGA), Raman spectroscopy, atomic force microscopy (AFM) topographic imaging, transmission electron microscopy (TEM), and surface morphology via scanning electron microscopy (SEM). Furthermore, ELA drug loading and release behaviours from ELA-GO nanocomposite were studied. The ELA-GO nanocomposite has a uniform size distribution averaging 88 nm and high drug loading capacity of 30 wt.%. The in vitro drug release behaviour of ELA from the nanocomposite was investigated by UV-Vis spectrometry at a wavelength of λmax 257 nm. The data confirmed prolonged ELA release over 5000 min at physiological pH (7.4). Finally, the IC50 of this ELA-GO nanocomposite was found to be 6.16 µg/ml against B16 cell line; ELA and GO did not show any cytotoxic effects up to 50 µg/ml on the same cell lines.
Keyphrases
- electron microscopy
- reduced graphene oxide
- atomic force microscopy
- quantum dots
- solid phase extraction
- high resolution
- drug release
- carbon nanotubes
- raman spectroscopy
- high speed
- visible light
- drug delivery
- photodynamic therapy
- highly efficient
- magnetic resonance imaging
- computed tomography
- adverse drug
- magnetic resonance
- electronic health record
- risk assessment
- machine learning
- data analysis
- drug induced
- soft tissue