RT-PCR assay to detect FGFR3::TACC3 fusions in formalin-fixed, paraffin-embedded glioblastoma samples.
Loudy P Priesterbach-AckleyJoyce van KuikBastiaan B J TopsAnna LasorellaAntonio IavaroneWim van HeckePierre A J T RobePieter WesselingWendy W J de LengPublished in: Neuro-oncology practice (2024)
fusions can successfully be performed on FFPE material, with a specificity of 100% and (due to limited primer sets) a sensitivity of 83.3%. This assay allows for the identification of potential targeted treatment options when only formalin-fixed tissue is available.
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