Australian genome-wide association study confirms higher female risk for adult glioma associated with variants in the region of CCDC26.
Karen AlpenClaire M VajdicRobert J MacInnisRoger L MilneEng-Siew KohElizabeth HoveyRosemary HarrupFiona BruinsmaTuong L NguyenSherly X LiDavid JosephGeza BenkePierre-Antoine DuguéMelissa C SoutheyGraham G GilesMark RosenthalKatharine J DrummondAnna K NowakJohn L HopperMiroslaw KapuscinskiEnes MakalicPublished in: Neuro-oncology (2022)
Our study supports a stronger female risk association for the region 8q24.21 CCDC26 and highlights the importance of analysing glioma GWAS by sex. A better understanding of sex differences could provide biological insight into the cause of glioma with implications for prevention, risk prediction and treatment.