Human Umbilical Cord Mesenchymal Stem Cell-derived Exosome Regulates Intestinal Type 2 Immunity.

Jiajun WuZhen YangDaoyuan WangYihui XiaoJia ShaoYun-Hai Liu

Published in: Current stem cell research & therapy (2024)

Our study demonstrates hUCMSC-Exo may benefit the host by increasing the tolerance at an early infection stage and then enhancing the intestinal type 2 immune response to impede the helminth during Th2 priming. Our results show hUCMSC-Exo may be a positive regulator of type 2 immune response, suggesting hUCMSC-Exo has a potential therapeutic effect on allergic diseases.

Keyphrases

umbilical cord
mesenchymal stem cells
immune response
endothelial cells
transcription factor
toll like receptor
risk assessment
dendritic cells
human health
allergic rhinitis