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Clinicopathological evaluation of the programmed cell death 1 (PD1)/programmed cell death-ligand 1 (PD-L1) axis in post-transplant lymphoproliferative disorders: association with Epstein-Barr virus, PD-L1 copy number alterations, and outcome.

Luis VelozaCristina TeixidoNatalia CastrejonFina ClimentAna CarrióMarta MarginetDavide SoldiniBlanca González-FarréInmaculada Ribera-CortadaArmando Lopez-GuillermoEva González-BarcaAdriana SierraMileyka HerreraCándida GómezAdriana GarciaOlga BalaguéElias CampoAntonio Martinez-Pozo
Published in: Histopathology (2019)
The PD1/PD-L1 axis is deregulated in post-transplant lymphoproliferative disorders, with frequent PD-L1 expression and PD1 negativity. PD-L1 expression is associated with EBV latency II or III and PD-L1 CNAs, and probably reflects a proinflammatory tumour microenvironment. The combined analysis of EBV status and PD-L1 expression may help to identify deeply immunosuppressed patients who can benefit from immune reconstitution approaches.
Keyphrases
  • epstein barr virus
  • copy number
  • diffuse large b cell lymphoma
  • mitochondrial dna
  • genome wide
  • stem cells
  • dna methylation
  • gene expression