Poly-adenine-mediated spherical nucleic acid probes for live cell fluorescence imaging of tumor-related microRNAs.

Qiuling QianGuifang HeChenguang WangShuainan LiXiaoshuang ZhaoYi XuXianqiang Mi

Published in: Molecular biology reports (2022)

The pASNA nanoprobes we developed had good sensitivity and specificity, excellent nuclease stability and low toxicity, thus representing a new approach to exquisitely reveal the distribution of endogenous miRNAs in live cells.

Keyphrases

fluorescence imaging
nucleic acid
photodynamic therapy
induced apoptosis
cell cycle arrest
oxidative stress
single cell
signaling pathway
gene expression
dna methylation
small molecule