Syndecan-4/PAR-3 signaling regulates focal adhesion dynamics in mesenchymal cells.
Alejandra ValdiviaAreli CárdenasMarianne BrenetHoracio MaldonadoMilene KongJorge DíazKeith BurridgePascal SchneiderAlejandra San MartínRafael García-MataAndrew F G QuestLisette LeytonPublished in: Cell communication and signaling : CCS (2020)
The newly identified Syndecan-4/PAR-3 signaling complex participates in Thy-1/CD90-induced focal adhesion disassembly in mesenchymal cells. The mechanism involves focal adhesion kinase dephosphorylation and Tiam1 activation downstream of Syndecan-4/PAR-3 signaling complex formation. Additionally, PAR-3 is defined here as a novel adhesome-associated component with an essential role in focal adhesion disassembly during polarized cell migration. These novel findings uncover signaling mechanisms regulating cell migration, thereby opening up new avenues for future research on Syndecan-4/PAR-3 signaling in processes such as wound healing and scarring.