The Impact of Persistent Leukoencephalopathy on Brain White Matter Microstructure in Long-Term Survivors of Acute Lymphoblastic Leukemia Treated with Chemotherapy Only.
Noah D SabinYin Ting CheungWilburn E ReddickDeepa BhojwaniWei LiuJohn O GlassTara M BrinkmanScott N HwangDeo Kumar SrivastavaChing-Hong PuiLeslie L RobisonMelissa M HudsonKevin R KrullPublished in: AJNR. American journal of neuroradiology (2018)
Leukoencephalopathy during active therapy and neurocognitive impairment at long-term follow-up are associated with microstructural white matter integrity. DTI may be more sensitive than standard MR imaging for detection of clinically consequential white matter abnormalities in childhood acute lymphoblastic leukemia survivors treated with chemotherapy and in children undergoing treatment.
Keyphrases
- white matter
- acute lymphoblastic leukemia
- young adults
- multiple sclerosis
- allogeneic hematopoietic stem cell transplantation
- locally advanced
- newly diagnosed
- childhood cancer
- bipolar disorder
- stem cells
- computed tomography
- loop mediated isothermal amplification
- combination therapy
- rectal cancer
- label free
- magnetic resonance
- real time pcr
- mesenchymal stem cells