Reduced Severity of Tissue Injury Within the Infarct May Partially Mediate the Benefit of Reperfusion in Ischemic Stroke.
Felix Chun Fai NgLeonid ChurilovNawaf YassiTimothy John KleinigVincent N ThijsTeddy Y WuDarshan G ShahHelen M DeweyGagan SharmaPatricia M DesmondBernard YanMark W ParsonsGeoffrey Alan DonnanStephen M DavisPeter J MitchellRichard LeighBruce C V Campbellnull nullPublished in: Stroke (2022)
In patients with ischemic stroke, reduced severity of tissue injury within the infarct, as determined by assessing the integrity of the BBB, is independently associated with improved functional outcome. In addition to reducing diffusion-weighted imaging-defined infarct volume, reperfusion may also improve clinical outcome by reducing tissue injury severity within the infarct.